Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
Identifieur interne : 000071 ( Main/Exploration ); précédent : 000070; suivant : 000072Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
Auteurs : Danila De Oliveira [Brésil] ; Jaqueline Suemi Hassumi [Brésil] ; Pedro Henrique Da Silva Gomes-Ferreira [Brésil] ; Tárik Ocon Braga Polo [Brésil] ; Gabriel Ramalho Ferreira [Brésil] ; Leonardo Perez Faverani [Brésil] ; Roberta Okamoto [Brésil]Source :
- Journal of Applied Oral Science [ 1678-7757 ] ; 2017.
Abstract
Sodium alendronate is a bisphosphonate drug that exerts antiresorptive action and is used to treat osteoporosis.
The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin).
A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level.
Bone volume (BV) and total pore volume were higher for ALE group (P<0.05). Molecular data for RUNX2 and BSP proteins were significantly expressed in the ALE group (P<0.05), in comparison with the other groups. ALP expression was higher in the CTL group (P<0.05). The immunostaining for RUNX2 and osteopontin was positive in the osteoblastic lineage cells of neoformed bone for the CTL and ALE groups in both periods (14 and 42 days). Alkaline phosphatase presented a lower staining area in the OST group compared to the CTL in both periods and the ALE at 42 days.
There was a decrease of osteocalcin precipitation at 42 days for the ALE and OST groups. Therefore, treatment with short-term sodium alendronate improved bone repair around the implants installed in the tibia of osteoporotic rats.
Url:
DOI: 10.1590/1678-77572016-0165
PubMed: 28198975
PubMed Central: 5289399
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002F85
- to stream Pmc, to step Curation: 002F85
- to stream Pmc, to step Checkpoint: 000064
- to stream Ncbi, to step Merge: 006E06
- to stream Ncbi, to step Curation: 006E06
- to stream Ncbi, to step Checkpoint: 006E06
- to stream Main, to step Merge: 000071
- to stream Main, to step Curation: 000071
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals</title><author><name sortKey="De Oliveira, Danila" sort="De Oliveira, Danila" uniqKey="De Oliveira D" first="Danila" last="De Oliveira">Danila De Oliveira</name><affiliation wicri:level="2"><nlm:aff id="aff1">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Hassumi, Jaqueline Suemi" sort="Hassumi, Jaqueline Suemi" uniqKey="Hassumi J" first="Jaqueline Suemi" last="Hassumi">Jaqueline Suemi Hassumi</name><affiliation wicri:level="2"><nlm:aff id="aff1">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Gomes Ferreira, Pedro Henrique Da Silva" sort="Gomes Ferreira, Pedro Henrique Da Silva" uniqKey="Gomes Ferreira P" first="Pedro Henrique Da Silva" last="Gomes-Ferreira">Pedro Henrique Da Silva Gomes-Ferreira</name><affiliation wicri:level="2"><nlm:aff id="aff2">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Polo, Tarik Ocon Braga" sort="Polo, Tarik Ocon Braga" uniqKey="Polo T" first="Tárik Ocon Braga" last="Polo">Tárik Ocon Braga Polo</name><affiliation wicri:level="2"><nlm:aff id="aff2">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Ferreira, Gabriel Ramalho" sort="Ferreira, Gabriel Ramalho" uniqKey="Ferreira G" first="Gabriel Ramalho" last="Ferreira">Gabriel Ramalho Ferreira</name><affiliation wicri:level="4"><nlm:aff id="aff3">Universidade de São Paulo, Hospital de Reabilitação de Anomalias Craniofaciais, Bauru, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade de São Paulo, Hospital de Reabilitação de Anomalias Craniofaciais, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Faverani, Leonardo Perez" sort="Faverani, Leonardo Perez" uniqKey="Faverani L" first="Leonardo Perez" last="Faverani">Leonardo Perez Faverani</name><affiliation wicri:level="2"><nlm:aff id="aff2">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Okamoto, Roberta" sort="Okamoto, Roberta" uniqKey="Okamoto R" first="Roberta" last="Okamoto">Roberta Okamoto</name><affiliation wicri:level="2"><nlm:aff id="aff1">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28198975</idno><idno type="pmc">5289399</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289399</idno><idno type="RBID">PMC:5289399</idno><idno type="doi">10.1590/1678-77572016-0165</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002F85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F85</idno><idno type="wicri:Area/Pmc/Curation">002F85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F85</idno><idno type="wicri:Area/Pmc/Checkpoint">000064</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000064</idno><idno type="wicri:Area/Ncbi/Merge">006E06</idno><idno type="wicri:Area/Ncbi/Curation">006E06</idno><idno type="wicri:Area/Ncbi/Checkpoint">006E06</idno><idno type="wicri:doubleKey">1678-7757:2017:De Oliveira D:short:term:sodium</idno><idno type="wicri:Area/Main/Merge">000071</idno><idno type="wicri:Area/Main/Curation">000071</idno><idno type="wicri:Area/Main/Exploration">000071</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals</title><author><name sortKey="De Oliveira, Danila" sort="De Oliveira, Danila" uniqKey="De Oliveira D" first="Danila" last="De Oliveira">Danila De Oliveira</name><affiliation wicri:level="2"><nlm:aff id="aff1">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Hassumi, Jaqueline Suemi" sort="Hassumi, Jaqueline Suemi" uniqKey="Hassumi J" first="Jaqueline Suemi" last="Hassumi">Jaqueline Suemi Hassumi</name><affiliation wicri:level="2"><nlm:aff id="aff1">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Gomes Ferreira, Pedro Henrique Da Silva" sort="Gomes Ferreira, Pedro Henrique Da Silva" uniqKey="Gomes Ferreira P" first="Pedro Henrique Da Silva" last="Gomes-Ferreira">Pedro Henrique Da Silva Gomes-Ferreira</name><affiliation wicri:level="2"><nlm:aff id="aff2">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Polo, Tarik Ocon Braga" sort="Polo, Tarik Ocon Braga" uniqKey="Polo T" first="Tárik Ocon Braga" last="Polo">Tárik Ocon Braga Polo</name><affiliation wicri:level="2"><nlm:aff id="aff2">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Ferreira, Gabriel Ramalho" sort="Ferreira, Gabriel Ramalho" uniqKey="Ferreira G" first="Gabriel Ramalho" last="Ferreira">Gabriel Ramalho Ferreira</name><affiliation wicri:level="4"><nlm:aff id="aff3">Universidade de São Paulo, Hospital de Reabilitação de Anomalias Craniofaciais, Bauru, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade de São Paulo, Hospital de Reabilitação de Anomalias Craniofaciais, Bauru, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Faverani, Leonardo Perez" sort="Faverani, Leonardo Perez" uniqKey="Faverani L" first="Leonardo Perez" last="Faverani">Leonardo Perez Faverani</name><affiliation wicri:level="2"><nlm:aff id="aff2">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Cirurgia e Clínica Integrada, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Okamoto, Roberta" sort="Okamoto, Roberta" uniqKey="Okamoto R" first="Roberta" last="Okamoto">Roberta Okamoto</name><affiliation wicri:level="2"><nlm:aff id="aff1">Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP, Brasil.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Brésil</country><wicri:regionArea>Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, Departamento de Ciências Básicas, Araçatuba, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Applied Oral Science</title><idno type="ISSN">1678-7757</idno><idno type="eISSN">1678-7765</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Sodium alendronate is a bisphosphonate drug that exerts antiresorptive action and is used to treat osteoporosis. </p><sec><title>Objective</title><p> The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin).</p></sec><sec><title>Material and Methods</title><p> A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level.</p></sec><sec><title>Results</title><p> Bone volume (BV) and total pore volume were higher for ALE group (P<0.05). Molecular data for RUNX2 and BSP proteins were significantly expressed in the ALE group (P<0.05), in comparison with the other groups. ALP expression was higher in the CTL group (P<0.05). The immunostaining for RUNX2 and osteopontin was positive in the osteoblastic lineage cells of neoformed bone for the CTL and ALE groups in both periods (14 and 42 days). Alkaline phosphatase presented a lower staining area in the OST group compared to the CTL in both periods and the ALE at 42 days.</p></sec><sec><title>Conclusion</title><p> There was a decrease of osteocalcin precipitation at 42 days for the ALE and OST groups. Therefore, treatment with short-term sodium alendronate improved bone repair around the implants installed in the tibia of osteoporotic rats.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abrahamsen, B" uniqKey="Abrahamsen B">B Abrahamsen</name></author><author><name sortKey="Eiken, P" uniqKey="Eiken P">P Eiken</name></author><author><name sortKey="Prieto Alhambra, D" uniqKey="Prieto Alhambra D">D Prieto-Alhambra</name></author><author><name sortKey="Eastell, R" uniqKey="Eastell R">R Eastell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akca, K" uniqKey="Akca K">K Akca</name></author><author><name sortKey="Sarac, E" uniqKey="Sarac E">E Sarac</name></author><author><name sortKey="Baysal, U" uniqKey="Baysal U">U Baysal</name></author><author><name sortKey="Fanuscu, M" uniqKey="Fanuscu M">M Fanuscu</name></author><author><name sortKey="Chang, Tl" uniqKey="Chang T">TL Chang</name></author><author><name sortKey="Cehreli, M" uniqKey="Cehreli M">M Cehreli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amugongo, Sk" uniqKey="Amugongo S">SK Amugongo</name></author><author><name sortKey="Yao, W" uniqKey="Yao W">W Yao</name></author><author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name></author><author><name sortKey="Dai, W" uniqKey="Dai W">W Dai</name></author><author><name sortKey="Lay, Ya" uniqKey="Lay Y">YA Lay</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aydo An, Nh" uniqKey="Aydo An N">NH Aydoğan</name></author><author><name sortKey="Ozel, " uniqKey="Ozel ">İ Özel</name></author><author><name sortKey=" Ltar, S" uniqKey=" Ltar S">S İltar</name></author><author><name sortKey="Kara, T" uniqKey="Kara T">T Kara</name></author><author><name sortKey="Ozmeric, A" uniqKey="Ozmeric A">A Özmeriç</name></author><author><name sortKey="Alemdaro Lu, Kb" uniqKey="Alemdaro Lu K">KB Alemdaroğlu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Busenlechner, D" uniqKey="Busenlechner D">D Busenlechner</name></author><author><name sortKey="Furhauser, R" uniqKey="Furhauser R">R Fürhauser</name></author><author><name sortKey="Hassh, R" uniqKey="Hassh R">R Hassh</name></author><author><name sortKey="Watzek, G" uniqKey="Watzek G">G Watzek</name></author><author><name sortKey="Mailathe, G" uniqKey="Mailathe G">G Mailathe</name></author><author><name sortKey="Pommer, B" uniqKey="Pommer B">B Pommer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cauley, Ja" uniqKey="Cauley J">JA Cauley</name></author><author><name sortKey="Robbins, J" uniqKey="Robbins J">J Robbins</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Cummings, Sr" uniqKey="Cummings S">SR Cummings</name></author><author><name sortKey="Jackson, Rd" uniqKey="Jackson R">RD Jackson</name></author><author><name sortKey="Lacroix, Az" uniqKey="Lacroix A">AZ LaCroix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chacon, Ge" uniqKey="Chacon G">GE Chacon</name></author><author><name sortKey="Stine, Ea" uniqKey="Stine E">EA Stine</name></author><author><name sortKey="Larsen, Pe" uniqKey="Larsen P">PE Larsen</name></author><author><name sortKey="Beck, Fm" uniqKey="Beck F">FM Beck</name></author><author><name sortKey="Mcglumphy, Ea" uniqKey="Mcglumphy E">EA McGlumphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Liu, N" uniqKey="Liu N">N Liu</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Qu, X" uniqKey="Qu X">X Qu</name></author><author><name sortKey="Lu, E" uniqKey="Lu E">E Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drage, Na" uniqKey="Drage N">NA Drage</name></author><author><name sortKey="Palmer, Rm" uniqKey="Palmer R">RM Palmer</name></author><author><name sortKey="Blake, G" uniqKey="Blake G">G Blake</name></author><author><name sortKey="Wilson, R" uniqKey="Wilson R">R Wilson</name></author><author><name sortKey="Crane, F" uniqKey="Crane F">F Crane</name></author><author><name sortKey="Fogelman, I" uniqKey="Fogelman I">I Fogelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ducy, P" uniqKey="Ducy P">P Ducy</name></author><author><name sortKey="Schinke, T" uniqKey="Schinke T">T Schinke</name></author><author><name sortKey="Karsenty, G" uniqKey="Karsenty G">G Karsenty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, Yp" uniqKey="Fan Y">YP Fan</name></author><author><name sortKey="Chen, Xy" uniqKey="Chen X">XY Chen</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Yang, Gl" uniqKey="Yang G">GL Yang</name></author><author><name sortKey="Wang, Hm" uniqKey="Wang H">HM Wang</name></author><author><name sortKey="He, Fm" uniqKey="He F">FM He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Javed, F" uniqKey="Javed F">F Javed</name></author><author><name sortKey="Almas, K" uniqKey="Almas K">K Almas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lekholm, U" uniqKey="Lekholm U">U Lekholm</name></author><author><name sortKey="Zarb, Ga" uniqKey="Zarb G">GA Zarb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liberman, Ua" uniqKey="Liberman U">UA Liberman</name></author><author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name></author><author><name sortKey="Geusens, P" uniqKey="Geusens P">P Geusens</name></author><author><name sortKey="Shah, A" uniqKey="Shah A">A Shah</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Chattopadhyay, A" uniqKey="Chattopadhyay A">A Chattopadhyay</name></author><author><name sortKey="Ross, Pd" uniqKey="Ross P">PD Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lirani Galvao, Ap" uniqKey="Lirani Galvao A">AP Lirani-Galvão</name></author><author><name sortKey="Lazaretti Castro, M" uniqKey="Lazaretti Castro M">M Lazaretti-Castro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, Ja" uniqKey="Long J">JA Long</name></author><author><name sortKey="Evans, Hm" uniqKey="Evans H">HM Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maeda, Ss" uniqKey="Maeda S">SS Maeda</name></author><author><name sortKey="Lazaretti Castro, M" uniqKey="Lazaretti Castro M">M Lazaretti-Castro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Pd" uniqKey="Miller P">PD Miller</name></author><author><name sortKey="Derman, Rj" uniqKey="Derman R">RJ Derman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, Kc" uniqKey="Oh K">KC Oh</name></author><author><name sortKey="Moon, Hs" uniqKey="Moon H">HS Moon</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Park, Yb" uniqKey="Park Y">YB Park</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paz, Lh" uniqKey="Paz L">LH Paz</name></author><author><name sortKey="Falco, V" uniqKey="Falco V">V Falco</name></author><author><name sortKey="Teng, Nc" uniqKey="Teng N">NC Teng</name></author><author><name sortKey="Reis, Lm" uniqKey="Reis L">LM Reis</name></author><author><name sortKey="Pereira, Rm" uniqKey="Pereira R">RM Pereira</name></author><author><name sortKey="Jorgetti, V" uniqKey="Jorgetti V">V Jorgetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramalho Ferreira, G" uniqKey="Ramalho Ferreira G">G Ramalho-Ferreira</name></author><author><name sortKey="Faverani, Lp" uniqKey="Faverani L">LP Faverani</name></author><author><name sortKey="Momesso, Gac" uniqKey="Momesso G">GAC Momesso</name></author><author><name sortKey="Luvizuto, Er" uniqKey="Luvizuto E">ER Luvizuto</name></author><author><name sortKey="Oliveira Puttini, I" uniqKey="Oliveira Puttini I">I Oliveira Puttini</name></author><author><name sortKey="Okamoto, R" uniqKey="Okamoto R">R Okamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramalho Ferreira, G" uniqKey="Ramalho Ferreira G">G Ramalho-Ferreira</name></author><author><name sortKey="Faverani, Lp" uniqKey="Faverani L">LP Faverani</name></author><author><name sortKey="Prado, Fb" uniqKey="Prado F">FB Prado</name></author><author><name sortKey="Ir, Garcia" uniqKey="Ir G">Garcia IR</name></author><author><name sortKey="Okamoto, R" uniqKey="Okamoto R">R Okamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggiero, Sl" uniqKey="Ruggiero S">SL Ruggiero</name></author><author><name sortKey="Dodson, Tb" uniqKey="Dodson T">TB Dodson</name></author><author><name sortKey="Assael, La" uniqKey="Assael L">LA Assael</name></author><author><name sortKey="Landesberg, R" uniqKey="Landesberg R">R Landesberg</name></author><author><name sortKey="Marx, Re" uniqKey="Marx R">RE Marx</name></author><author><name sortKey="Mehrotra, B" uniqKey="Mehrotra B">B Mehrotra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salmon, B" uniqKey="Salmon B">B Salmon</name></author><author><name sortKey="Bardet, C" uniqKey="Bardet C">C Bardet</name></author><author><name sortKey="Coyac, Br" uniqKey="Coyac B">BR Coyac</name></author><author><name sortKey="Baroukh, B" uniqKey="Baroukh B">B Baroukh</name></author><author><name sortKey="Naji, J" uniqKey="Naji J">J Naji</name></author><author><name sortKey="Rowe, Ps" uniqKey="Rowe P">PS Rowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapurian, T" uniqKey="Shapurian T">T Shapurian</name></author><author><name sortKey="Damoulis, Pd" uniqKey="Damoulis P">PD Damoulis</name></author><author><name sortKey="Reiser, Gm" uniqKey="Reiser G">GM Reiser</name></author><author><name sortKey="Griffin, Tj" uniqKey="Griffin T">TJ Griffin</name></author><author><name sortKey="Rand, Wm" uniqKey="Rand W">WM Rand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Te Filo, Jm" uniqKey="Te Filo J">JM Teófilo</name></author><author><name sortKey="Azevedo, Ac" uniqKey="Azevedo A">AC Azevedo</name></author><author><name sortKey="Petenusci, So" uniqKey="Petenusci S">SO Petenusci</name></author><author><name sortKey="Mazaro, R" uniqKey="Mazaro R">R Mazaro</name></author><author><name sortKey="Lamano Carvalho, Tl" uniqKey="Lamano Carvalho T">TL Lamano-Carvalho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Te Filo, Jm" uniqKey="Te Filo J">JM Teófilo</name></author><author><name sortKey="Brentegani, Lg" uniqKey="Brentegani L">LG Brentegani</name></author><author><name sortKey="Lamano Carvalho, Tl" uniqKey="Lamano Carvalho T">TL Lamano-Carvalho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verzola, Mh" uniqKey="Verzola M">MH Verzola</name></author><author><name sortKey="Frizzera, F" uniqKey="Frizzera F">F Frizzera</name></author><author><name sortKey="Oliveira, Gj" uniqKey="Oliveira G">GJ Oliveira</name></author><author><name sortKey="Pereira, Rm" uniqKey="Pereira R">RM Pereira</name></author><author><name sortKey="Rodrigues, Up" uniqKey="Rodrigues U">UP Rodrigues</name></author><author><name sortKey="Nonaka, Ko" uniqKey="Nonaka K">KO Nonaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Wowern, N" uniqKey="Von Wowern N">N Von Wowern</name></author><author><name sortKey="Kollerup, G" uniqKey="Kollerup G">G Kollerup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wazen, Rm" uniqKey="Wazen R">RM Wazen</name></author><author><name sortKey="Currey, Ja" uniqKey="Currey J">JA Currey</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author><author><name sortKey="Brunski, Jb" uniqKey="Brunski J">JB Brunski</name></author><author><name sortKey="Helms, Ja" uniqKey="Helms J">JA Helms</name></author><author><name sortKey="Nanci, A" uniqKey="Nanci A">A Nanci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whyte, Mp" uniqKey="Whyte M">MP Whyte</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="De Oliveira, Danila" sort="De Oliveira, Danila" uniqKey="De Oliveira D" first="Danila" last="De Oliveira">Danila De Oliveira</name></region><name sortKey="Faverani, Leonardo Perez" sort="Faverani, Leonardo Perez" uniqKey="Faverani L" first="Leonardo Perez" last="Faverani">Leonardo Perez Faverani</name><name sortKey="Ferreira, Gabriel Ramalho" sort="Ferreira, Gabriel Ramalho" uniqKey="Ferreira G" first="Gabriel Ramalho" last="Ferreira">Gabriel Ramalho Ferreira</name><name sortKey="Gomes Ferreira, Pedro Henrique Da Silva" sort="Gomes Ferreira, Pedro Henrique Da Silva" uniqKey="Gomes Ferreira P" first="Pedro Henrique Da Silva" last="Gomes-Ferreira">Pedro Henrique Da Silva Gomes-Ferreira</name><name sortKey="Hassumi, Jaqueline Suemi" sort="Hassumi, Jaqueline Suemi" uniqKey="Hassumi J" first="Jaqueline Suemi" last="Hassumi">Jaqueline Suemi Hassumi</name><name sortKey="Okamoto, Roberta" sort="Okamoto, Roberta" uniqKey="Okamoto R" first="Roberta" last="Okamoto">Roberta Okamoto</name><name sortKey="Polo, Tarik Ocon Braga" sort="Polo, Tarik Ocon Braga" uniqKey="Polo T" first="Tárik Ocon Braga" last="Polo">Tárik Ocon Braga Polo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000071 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000071 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5289399
|texte= Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28198975" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |